1. Dingze Mang+, Sona Rani Roy+,  Qizheng Zhang+, Xunwu Hu, Ye Zhang*. "Heparan-Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration" ACS Applied Materials & Interfaces, 2021, accepted. (+ These authors contributed equally to this work).

  2. Guanying Li+, Xunwu Hu+,  Xia Wu, Ye Zhang*. " Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth" Nano Letters, 2021, accepted. (+ These authors contributed equally to this work).


  3. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Yazhou chen, Toshio Sasaki, Hui Chao,* and Ye Zhang.* "Construct Sturdy Packing of Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking" Angew. Chem. Int. Ed. 2021.



  1. Guanying Li, Xunwu Hu, Pingping Nie, Dingze Mang, Shi Jiao, Shijin Zhang, Sona Roy, Sachie Yukawa, Shunsuke Asahina, Hiroaki Sugasawa, William Cortes, Zhaocai Zhou,* and Ye Zhang.* "Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Treat Ovarian Cancer" Nano Letters, 2020,


  2. Xia Wu, Xunwu Hu, and Ye Zhang.* "Regulate Cellular Responses via Molecular Assembly in Cell Milieu for Cancer Therapy" (Highlight Review) Chemistry Letters, 2020.


  3. Guanying Li, William Cortes, Qizheng Zhang, and Ye Zhang.* "Chemical Oscillation and Morphological Oscillation in Catalyst-embedded Lyotropic Liquid Cristalline Gels" Frontiers in Chemistry, 2020,


  4. Shijin Zhang, and Ye Zhang.* "Promote Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly" ACS Applied Materials & Interfaces, 2020, 12, 37, 41105-41112.


  5. Jiaqing Wang, Weiyi Tan, Guanying Li, Difei Wu, Hongjian He, Jiashu Xu, Meihui Yi, Ye Zhang, S. Ali Aghvami, Seth Fraden, Bing Xu.* "Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Cancer Cells" Chem. Eur. J. 2020,

  6. Shijin Zhang, William Cortes, and Ye Zhang.* "Constructing Cross-linked Nanofibrous Scaffold via Dual-Enzyme-Instructed Hierarchical AssemblyLangmuir, 2020, 36, 6261-6267.


  7. Sona Rani Roy, Guanying Li, Xunwu Hu, Shijin Zhang, Sachie Yukawa, Enming Du, and Ye Zhang.* "Integrin and Heparan Sulfate Dual-tageting Peptide Assembly Suppresses Cancer Metastasis" ACS Applied Materials & Interfaces, 2020, 17, 19277-19284.                                                     

  8. Dingze Mang,+ Sona Rani Roy,+ Hong Huat Hoh, Xia Wu, Jiahao Zhang, Chengzhi Jin, and Ye Zhang.* "Self-Assembly of Integrin Ligands on the Apical Membrane Inhibits the Migration of Glioma CellsLangmuir2020, 14, 3750-3757. (+ These authors contribute equally to this work).


  9. Shijin Zhang1,+, William Cortes1,+, Toshio Sasaki2, Shunsuke Asahina3, Asano Natsuko3, Qizheng Zhang1, and Ye Zhang.1,* "Mechanoresponsive Alignment of Molecular Self-assembled Negatively Charged NanofibrilsACS Applied Bio Materials. 2020, 3, 1698-1704 (+These authors contribute equally to this work).



  1. Shijin Zhang, Xunwu Hu, Dingze Mang, Toshio Sasaki, and Ye Zhang.* "Self-delivery of N-hydroxylethyl Peptide Assemblies to the Cytosol Inducing Endoplasmic Reticulum Dilation in Cancer Cells Chem. Commun. 2019, 55, 7474-7477.

  2. Dingze Mang,+ Shijin Zhang,+ Xia Wu, Toshiaki Mochizuki, Guanying Li, and Ye Zhang.* "Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect" Chem. Commun. 2019, 55, 6126 - 6129  (+These authors contribute equally to this work)


  1. Enming Du, Xunwu Hu, Guanying Li, Shijin Zhang, Dingze Mang, Sona Roy, Toshio Sasaki, and Ye Zhang.* "Self-assembly-Directed Cancer Cell Membrane Insertion of Synthetic Ananlogues for Permeability Alteration" Langmuir2019, 35, 7376 - 7382.


  2. Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, and Ye Zhang.* "Regulate  Higher-order Organization through the Synergy of Two Self-sorted Assemblies" Angew. Chem. Int. Ed. 2018, 57, 3636-3640


  1. Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiaki Mochizuki and Ye Zhang.* "Taurine-Modified Ru(II)-Complex Targets Cancerous Brain Cells for Photodynamic Therapy" Chem. Commun. 2017, 53, 6033-6036


  2. Wei Ji, Shijin Zhang, Gerogy A. Filonenko, Guanying Li, Toshio Sasaki, Chuanliang Feng* and Ye Zhang.* "Co-Organizing Synthesis of Heterogeneous Nanostructure through Photo-Cleavage of Pre-Stabilized Self-Assemblies" Chem. Commun. 2017, 53, 4702-4705.


  3. Guanying Li, Toshio Sasaki, Shunsuke Asahina, Michael C. Roy, Toshiaki Mochizuki, Koji Koizumi  and Ye Zhang.* “Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration” Chem2017, 2, 283-298.


  1. Yunhui Zheng, Guanying Li and Ye Zhang.* "Organometallic Hydrogels" ChemNanoMat, 2016, 2, 364-375.

  2. Qingcong Wei, Mengchi Xu, Chuanan Liao, Qing Wu, Mingyu Liu, Ye Zhang,* Chengtie Wu,* Liming Cheng and Qigang Wang.*  "Printable hybrid hydrogel by dual enzymatic polymerization with superactivity" Chemical Science, 2016, 7, 2748.

Before moving to OIST

  1. Zhang, Y.; Zhou, N.; Shi, J. F.; Pochapsky, S. S.; Pochapsky, T. C.; Zhang, B.; Zhang, X. X.; Xu, B.* “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nature Commun. 2015, 6, 6165.
  2. Shi, J. F.; Du, X. W.; Huang, Y. B.; Zhou, J.; Yuan, D.; Wu, D. D.; Zhang, Y.; Haburcak, R.; Eptein, I. R.*; Xu, B.* “Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis” J. Am. Chem. Soc. 2015, 137, 26.
  3. Park, S.; Kim, D.; Ko, S. Y.; Park, J-O., Akella S., Xu, B., Zhang, Y.; Fraden, S.* “Controlling uniformity of photo-polymerized microscopic hydrogels” Lab on a Chip. 2014, 14, 1551-1563.
  4. Zhang, Y.; Zhou, N.; Kim, D.; Fraden, S.*; Epstein, I. R.*; Xu, B.* “ Giant Volume Change of Active Gels under Continuous Flow” J. Am. Chem. Soc., 2014, 136, 7341-7347.
  5. Zhang, Y.; Zhou, N.; Akella, S.; Kuang, Y.; Kim, D.; Schwartz, A.; Bezpalko, M.; Foxman, B. M.; Fraden, S.; Epstein, I. R.*; Xu, B.* “ Active Hyper Crosslinkers Confer Active Gels” Angew. Chem. Int. Ed. 2013, 52, 6944-6948.
  6. Zhang, Y.; Zhou, R.; Shi, J.; Zhou, N.; Epstein, I. R.; Xu, B.* “Post-Self-Assembly Cross-Linking to Integrate Molecular Nanofibers with Copolymers in Oscillatory Hydrogels” J. Phys. Chem. B, 2013, 117, 6566-6573.
  7. Zhang, Y.; Zhang, B.; Kuang, Y.; Gao, Y.; Shi, J.; Zhang, X. X.; Xu, B.* “A Redox Responsive, Fluorescent Supramolecular Metallohydrogel Consists of Nanofibers with Single-Molecule Width” J. Am. Chem. Soc., 2013, 135, 5008-5011.
  8. Kuang, Yi.; Yuan, D.; Zhang, Y.; Du, X. W.; Xu, B.* “Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules” RSC Advances, 2013, 3, 7704-7707.
  9. Yang, Z. M.; Kuang, Y.; Li, X. M.; Zhou, N.; Zhang, Y.; Xu, B.* “Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA” Chem. Commun. 2012, 48, 9257-9259.
  10. Zhang, Y.; Li, N.; Delgado, J.; Zhou, N.; Yoshida, R.; Fraden, S.; Epstein, I. R.*; Xu, B.* “Structural modulation of self-oscillating gels: Changing the proximity of the catalyst to the polymer backbone to tailor chemomechanical oscillation” Soft Matter, 2012, 8, 7056-7061.
  11. Zhang, Y.; Li, N.; Delgado, J.; Gao, Y.; Kuang, Y.; Fraden, S.; Epstein, I. R.*; Xu, B.* “Post-Self-Assembly Crosslinking of Molecular Nanofibers for Oscillatory Hydrogels” Langmuir, 2012, 28, 3063-3066.
  12. Zhang, Y.; Xu, B. “Multifunctional Magnetic Nanoparticles as Bionanomaterials” American Institute of Biological Sciences, 2011, July.
  13. Delgado, J.; Zhang, Y.; Xu, B.; Epstein, I. R. “Terpyridine- and Bipyridine-Based Ruthenium Complexes as Catalysts for the Belousov-Zhabotinsky Reaction” J. Phys. Chem. A, 2011, 115, 2208-2215.
  14. Shi, J. F.; Gao, Y.; Zhang, Y.; Pan, Y.; Xu, B.* “Calcium Ions to Crosslink Supramolecular Nanofibers to Tune the Elasticity of Hydrogels over Orders of Magnitude” Langmuir, 2011, 27, 14425-14431.
  15. Zhang, Y.; Yousef, Y. A.; Li, H.; Melø, T. B.; Naqvi, K. R.* “Comparison of the photochemical behaviors of α-tocopherol and its acetate in organic and aqueous micellar solutions” J. Phy. Chem. A. 2011, 29, 8242-8247.
  16. Zhang, Y.; Kuang, Y.; Gao, Y.; Xu, B.* “Versatile Small Molecule Motifs for Self-assembly in Water and Formation of Biofunctional Supramolecular Hydrogels” Langmuir, 2011, 27, 529-537.
  17. Gao, Y.; Zhao, F.; Wang, Q. G.; Zhang, Y.; Xu, B.* “Small Peptide Nanofibers as the Matrices of Molecular Hydrogels for Mimicking Enzymes and Enhancing the Activity of Enzymes” Chem. Soc. Rev. 2010, 39, 3425-3433.
  18. Dai, W-M.*; Li, Y.; Zhang, Y.; Yue, C.; Wu, J. “Generation of an Aromatic Amide-Derived Phosphane (Aphos) Library by Self-Assisted Molecular Editing and Applications of Aphos in Room-Temperature Suzuki-Miyaura Reactions” Chem. Eur. J. 2008, 14, 5538-5554.
  19. Dai, W-M.*; Zhang, Y. “A Family of Simple Amide-Derived Air-Stable P,O-Ligands for Suzuki Cross-Coupling of Unactivated Aryl Chlorides” Tetrahedron Lett. 2005, 46, 1377-1381.
  20. Dai, W-M.*; Li, Y.; Zhang, Y.; Lai, K. W.; Wu, J. “A Novel Class of Amide-Derived Air-Stable P,O-Ligands for Suzuki Cross-Coupling at Low Catalyst Loading” Tetrahedron Lett. 2004, 45, 1999-2001.
  21. Dai. W-M.*; Zhang, Y.; Zhang, Y. “Synthesis of Atropisomeric 2,8-Dioxygenated N,N-Diisopropyl-1-naphthamides via Kinetic Resolution under the Sharpless Asymmetric Dihydroxylation Conditions” Tetrahedron: Asymmetry 2004, 15-525-535.
  22. Dai, W-M.*; Yeung, K. Y.; Liu, J-T.; Zhang, Y.; Williams, I. D. “A Novel Class of Nonbiaryl Atropisomeric P,O-Ligands for Palladium-Catalyzed Asymmetric Allylic Alkyation” Org. Lett. 2002, 4, 1615-1618.