政井一郎
教授
Bsc, Msc, PhD (University of Tokyo)
国籍
日本
学歴
1988 東京大学 理学部 物理学科卒業
1990 東京大学大学院 理学系研究科 物理学専攻 修士課程修了
1992 東京大学大学院 理学系研究科 物理学専攻 博士課程中退
1994 理学博士取得 （東京大学大学院、論文博士）
職歴
1992 東京大学 遺伝子実験施設 助手
1995 ロンドン大学 キングスカレッジ 研究員 (HFSP海外留学助成)
1998 理化学研究所 脳科学総合研究センター 研究員
2000 JSTさきがけ研究員
2001 (独) 理化学研究所 独立主幹研究員（ユニットリーダー）
2006 (独) 沖縄科学技術研究基盤整備機構 神経発生ユニット 代表研究者
2011 沖縄科学技術大学院大学 神経発生ユニット 准教授
2019 沖縄科学技術大学院大学 神経発生ユニット 教授
主な業績
Chiang, H.-J., Nishiwaki, Y., Chiang, W.-C., and Masai, I. (2024) Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Dis. Model Mech. dmm.050618. doi: 10.1242/dmm.050618.
Sugiyama, Y., Reed, D., Herrmann, D., Lovicu, F., Robinson, M.L., Timpson, P., and Masai, I. (2024) Fibroblast Growth Factor-induced lens fiber elongation is driven by Rho and Rac. Development 151, dev.202123. doi:10.1242/dev.202123.
Babu, S., Takeuchi, Y. and Masai, I. (2022) Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. eLife. 11:e74611. doi: 10.7554/eLife.74611.
Ahmed, M, Kojima, Y., and Masai, I. (2022) Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote neural curcuit formation. eLife. 11:e74650. doi:10.7554/eLife.74650.
Ranawat, N., and Masai, I. (2021) Mechanism underlying microglial colonization of developing neural retina in zebrafish. eLife. 10:e70550. doi:10.7554/eLife.70550.
Nishiwaki, Y., and Masai, I. (2020) β-SNAP activity in the outer segment growth period is critical for preventing BNip1-dependent apoptosis in zebrafish photoreceptors. Sci. Rep. 10: 17379.
Iribarne, M., Hyde, D. R. and Masai, I. (2019) TNFa induces Müller glia to transition from non-proliferative gliosis to a regenerative response in mutant zebrafish presenting chronic photoreceptor degeneration. Front. Cell Dev. Biol. 7, 296. DOI:10.3389/fcell.2019.00296
Mochizuki, T., Kojima, Y., Nishiwaki, Y., Harakuni, T., and Masai, I. (2018) Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish. Development, 145, pii dev170282.
Iribarne, M. Nishiwaki, Y., Nakamura, S., Araragi, M., Oguri, E. and Masai, I. (2017) Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci. Rep. 7:45962.
Mochizuki, T., Luo, Y. J. Tsai, H. F. Hagiwara, A., and Masai, I. (2017) Cell division and cadherin-mediated adhesion regulates lens epithelial cell movement in zebrafish. Development 144, 708 – 719.
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I. (2013). The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Dev. Cell 25, 374 – 387.
Imai, F., Yoshizama, A., Fujimori-Tonou, N., Masai, I. (2010) The ubiquitin proteasome system is required for cell-cycle progression of the lens epithelium and differentiation of lens fiber cells in zebrafish. Development 137, 3257-3268.
Yamaguchi M, Fujimori-Tonou N, Yoshimura Y, Kishi T, Okamoto H, Masai I. (2008) Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53. Development 135, 1247-1257.
Yamaguchi M, Tonou-Fujimori N, Komori A, Maeda R, Nojima Y, Li H, Okamoto H, Masai I. (2005). Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. Development 132, 3027-3043.
Masai I, Yamaguchi M, Tonou-Fujimori N, Komori A, Okamoto H. (2005) The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation. Development 132, 1539-1553.
Masai I, Lele Z, Yamaguchi M, Komori A, Nakata A, Nishiwaki Y, Wada H, Tanaka H, Nojima Y, Hammerschmidt M, Wilson SW, Okamoto H. (2003) N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites. Development 130, 2479-2494.
Masai I, Stemple DL, Okamoto H, Wilson SW. (2000) Midline signals regulate retinal neurogenesis in zebrafish. Neuron 27, 251-263.
Masai I, Heisenberg CP, Barth KA, Macdonald R, Adamek S, Wilson SW. (1997) floating head and masterblind regulate neuronal patterning in the roof of the forebrain. Neuron 18, 43-57.
Masai I, Okazaki A, Hosoya T, Hotta Y. (1993) Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats. Proc. Natl. Acad. Sci. USA. 90, 11157-11161.
Masai I, Hosoya T, Kojima S, Hotta Y. (1992) Molecular cloning of a Drosophila diacylglycerol kinase gene that is expressed in the nervous system and muscle. Proc. Natl. Acad. Sci. USA. 89, 6030-6034.