Ichiro Maruyama


PhD (University of Tokyo)



Research Career

  • National Institute of Genetics, Mishima, Japan
  • MRC Laboratory of Molecular Biology, Cambridge, UK
  • MRC Molecular Genetics Unit, Cambridge, UK
  • The Scripps Research Institute, La Jolla, California, USA
  • Molecular Sciences Institute, Berkeley, California, USA
  • Genome Institute of Singapore, Singapore
  • Okinawa Instiute of Science & Technology (OIST), Okinawa, Japan
  • OIST Graduate University, Okinawa, Japan

Recent Selected Publications: 

  • Kawamura, K. and Maruyama, I. N. (2020). Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans. Aging. (doi: 10.18632/aging.202296)
  • Kawamura, K. and Maruyama, I. N. (2019) Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan. G3. (https://doi.org/10.1534/g3.119.400241)
  • Shindou, T., Ochi-Shindou, M., Murayama, T., Momohara, Y., Saita, E.-i., Wickens, J. R. and Maruyama, I. N. (2019). Active propagation of dendritic electrical signals in C. elegans. Scientific Reports. (doi: 10.1038/s41598-019-40158-9)
  • Murayama, T.and Maruyama, I. N. (2018) Plate Assay to Determine Caenorhabditis elegans Response to Water Soluble and Volatile Chemicals. bio-protocol. (doi: 10.21769/BioProtoc.2740)
  • Endang, P. R.,Saita, E.-i.and Maruyama, I. N. (2017) Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”. Cells. (doi:10.3390/cells6020013)
  • Nishijima, S.and Maruyama, I. N. (2017) Appetitive Olfactory Learning and Long-Term Associative Memory in Caenorhabditis elegans. Front. Behav. Neurosci. (http://dx.doi.org/10.3389/fnbeh.2017.00080)
  • Canu, N.,Pagano, I.,La Rosa, L. R.,Pellegrino, M.,Ciotti, M. T.,Mercanti, D.,Moretti, F.,Sposato, V.,Triaca, V.,Petrella, C.,Maruyama, I. N.,Levi, A.and Calissano, P. (2017) Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front. Mol. Neurosci. (https://doi.org/10.3389/fnmol.2017.00015)
  • Maruyama, I. (2017) Receptor Guanylyl Cyclases in Sensory Processing. Frontiers in Endocrinology.(doi:10.3389/fendo.2016.00173)
  • Maruyama, I. N. (2015) Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model". Bioessays. (doi: 10.1002/bies.201500041)
  • Murayama, T.and Maruyama, I. N. (2015) Alkaline pH sensor molecules. J Neurosci Res. (doi:10.1002/jnr.23621)
  • Maruyama, I. N. (2014) Mechanisms of activation of receptor tyrosine kinases: monomers or dimers. Cells. (doi:10.3390/cells3020304)
  • Sassa, T.and Maruyama, I. (2013) A G-protein α subunit, GOA-1, plays a role in C. elegans avoidance behavior of strongly alkaline pH. Communicative & Integrative Biology. (doi:10.4161/cib.26668)
  • Murayama, T.and Maruyama, I. (2013) Decision making in C. elegans chemotaxis to alkaline pH: Competition between two sensory neurons, ASEL and ASH. Communicative & integrative biology. (doi:10.4161/cib.26633)
  • Sassa, T.,Murayama, T.and Maruyama, I. (2013) Strongly alkaline pH avoidance mediated by ASH sensory neurons in C. elegans. Neurosci Lett. (doi:10.1016/j.neulet.2013.06.001) (Plenary Article Award)
  • Murayama, T.,Takayama, J.,Fujiwara, M.and Maruyama, I. (2013) Environmental Alkalinity Sensing Mediated by the Transmembrane Guanylyl Cyclase GCY-14 in C. elegans. Current Biology. (doi:10.1016/j.cub.2013.04.052)
  • Shen, J.and Maruyama, I. N. (2012) Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells. J Mol Signal. (10.1186/1750-2187-7-2)
  • Amano, H.and Maruyama, I. N. (2011) Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans. Learn Mem. (10.1101/lm.2224411)
  • Shen, J.and Maruyama, I. N. (2011) Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells. FEBS Lett. (10.1016/j.febslet.2010.12.031)
  • Trujillo, G.,Nakata, K.,Yan, D.,Maruyama, I. N.and Jin, Y. (2010) A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. Genetics. (10.1534/genetics.110.117341)

Full publications and employment history



Manuscript reviewer and editor (recent)