Ichiro Maruyama


PhD (University of Tokyo)



Research Career

  • National Institute of Genetics, Mishima, Japan
  • MRC Laboratory of Molecular Biology, Cambridge, UK
  • MRC Molecular Genetics Unit, Cambridge, UK
  • The Scripps Research Institute, La Jolla, California, USA
  • Molecular Sciences Institute, Berkeley, California, USA
  • Genome Institute of Singapore, Singapore
  • Okinawa Instiute of Science & Technology (OIST), Okinawa, Japan
  • OIST Graduate University, Okinawa, Japan

Recent Selected Publications: 

  • Murayama, T., Maruyama,I.N. (2018) Plate Assay to Determine Caenorhabditis elegans Response to Water Soluble and Volatile Chemicals. bio-protocol. (doi: 10.21769/BioProtoc.2740)
  • Purba, E. R., Saita, E., Maruyama, I.N. (2017) Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model” Cells (doi:10.3390/cells6020013)
  • Nishijima, S., Maruyama, I.N. (2017) Appetitive olfactory learning and long-term associative memory in Caenorhabditis elegans. Front. Behav. Neurosci. (doi: 10.3389/fnbeh.2017.00080).   
  • Canu, N., Pagano, I., La Rosa, L. R., Pellegrino, M., Ciotti, M. T., Mercanti, D., Moretti, F., Sposato, V., Triaca, V., Petrella, C., Maruyama, I., Levi, A. and Calissano, P. (2017) Association of TrkA and APP is promoted by NGF and reduced by cell death-promoting agents. Front. Mol. Neurosci.  (doi: 10.3389/fnmol.2017.00015).  
  • ​Maruyama, I. N. (2017) Receptor guanylyl cyclases in sensory processing. Front. Endocrinol 7, 173 (doi: 10.3389/fendo.2016.00173). 
  • Maruyama, I. N. (2015) Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model." (Invited Review). BioEssays 37, 959-967 (doi: 10.1002/bies.201570091).  
  • Murayama, T. and Maruyama, I. N. (2015) Alkaline pH sensor molecules. Journal of Neuroscience Research 93, 1623-1630 (DOI: 10.1002/jnr.23621).  
  • Maruyama, I. N. (2014) Mechanisms of activation of receptor tyrosine kinases: monomers or dimers (Invited Review). Cells 3, 304-330 (doi:10.3390/cells3020304).  
  • Sassa, T. and Maruyama, I. N. A G-protein α subunit, GOA-1, plays a role in C. elegans avoidance behavior of strongly alkaline pH. Communicative & Integrative Biology (2013) 6:e26668.   
  • Murayama, T. and Maruyama, I. N. (2013) Decision making in C. elegans chemotaxis to alkaline pH: Competition between two sensory neurons, ASEL and ASH. Communicative & Integrative Biology 6, e26633. http://dx.doi.org/10.1016/j.cub.2013.04.052; PMID: 23664973.  
  • Sassa, T., Murayama, T. and Maruyama, I. N. (2013) Strongly alkaline pH avoidance mediated by ASH sensory neurons in C. elegans (Plenary Article Award) Neuroscience Letters 555, 248-252. http://dx.doi.org/10.1016/j.neulet.2012.06.001  
  • Murayama, T., Takayama, J., Fujiwara, M. and Maruyama, I. N. (2013) Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.  Current Biology 23, 1007-1012.   
  • Shen, J. and Maruyama, I. N. (2012) Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells. Journal of Molecular  Signaling 7, 2. Doi:10.1186/1750-2187-7-2  
  • Amano, H., and Maruyama, I. N. (2011) Aversive olfactory learning and associative long-term memory in Caenorhabditis elegansLearning & Memory 18, 654-665.   
  • Shen, J. and Maruyama I. N. (2011) Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells. FEBS Letters 585, 295-299.  
  • Trujilla, G., Nakata, K., Yan, D., Maruyama, I. N., and Jin, Y. (2010) A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegansGenetics 186, 135-145.  

Full publications and employment history



Manuscript reviewer and editor (recent)