• Xu X, Kanai R, Wang L, Yanagida M (2022) Single amino acid substitutions in hydrophobic cores at a head-coiled coil junction region of cohesin facilitate its release of DNA during anaphase. Open Biol12(4) 2046-2441 [Open Biology]
  • Kondoh H, Teruya T, Chen YJ, Fukuji Y, Yanagida M (2022) Reply to Zheng et al.: Clinical metabolomics: detailed analysis by non-targeted method is complementary to large-scale studies. Proc Natl Acad Sci USA (PNAS). 119(5) [PubMed]
  • Kondoh H, Teruya T, Kameda M, Yanagida M (2022) Decline of ergothioneine in frailty and cognition impairment. FEBS Letter 10.1002/1873-3468.14299 [PubMed]


  • Teruya T, Goga H, Yanagida M (2021) Human age-declined saliva metabolic markers determined by LC-MS. Scientific Reports 11. Article number 18135 [Scientific reports]
  • Teruya T, Chen YJ, Kondoh H, Fukuji Y, Yanagida M (2021) Whole blood metabolomics of dementia patients reveal classes of disease-linked metabolites. Proc Natl Acad Sci USA (PNAS). 118(37) [PubMed]
  • Kameda M, Teruya T, Yanagida M, Kondoh H (2021) Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty. Aging (Albany NY) [PubMed]
  • Uehara L, Saitoh S, Mori A, Sajiki K, Toyoda U, Masuda F, Soejima S, Tahara Y, Yanagida M(2021)Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins. Open Biol. 11(4):200369 [PubMed]
  • Kameda M, Teruya T, Yanagida M, Kondoh H (2021) Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment. Proc Natl Acad Sci USA (PNAS) [PubMed]


  • Kondoh H, Kameda M, Yanagida M (2020) Whole Blood Metabolomics in Aging Research. Int J Mol Sci [PubMed]
  • Teruya T, Goga H, Yanagida M (2020) Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study. FASEB BioAdvances [FASEB]
  • Kondoh H, Teruya T, Yanagida M (2020) Metabolomics of human fasting: new insights about old questions. Open Biol [Royal Society Publishing]
  • Kameda M, Teruya T, Yanagida M, Kondoh H (2020) Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility. Proc Natl Acad Sci USA (PNAS) [PubMed]


  • Nakazawa N, Arakawa O, Yanagida M (2019) Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts. Open Biol. [PubMed]
  • Nakazawa N, Xu X, Arakawa O, Yanagida M (2019) Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn2+-Transporting, P-Type ATPase, Pmr1, in Fission Yeast.  G3 (Bethesda) [PubMed]
  • Xu X, Yanagida M (2019) Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation. Pcoc Natl Acad Sci USA (PNAS) [PubMed]
  • Xu X, Nakazawa N, Wang L, Arakawa O, Yanagida M (2019) Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex in Schizosaccharomyces pombe. G3 (Bethesda) [PubMed]
  • Xu X, Yanagida M (2019) Isolation of Fission Yeast Condensin Temperature-Sensitive Mutants with Single Amino Acid Substitutions Targeted to Hinge Domain. G3 (Bethesda) [PubMed]
  • Nakazawa N, Arakawa O, Ebe M, Yanagida M (2019) Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast. J Biol Chem [PubMed]
  • Teruya T, Chaleckis R, Takada J, Yanagida M, Kondoh H (2019) Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood. Scientific Reports 9. Article number 854 [Scientific Reports]


  • Sajiki K, Tahara Y, Uehara L, Sasaki T, Pluska T, Yanagida M (2018) Genetic regulation of mitotic competence in G0 quiescent cells. Science Advances. 4 (8): eaat5685 [Science Advances]
  • Hayashi T, Teruya T, Chaleckis R, Morigasaki S, Yanagida M (2018) S-Adenosylmethionine Synthetase Is Required for Cell Growth, Maintenance of G0 Phase, and Termination of Quiescence in Fission Yeast. iScience. 5:38-51 [PubMed] [iScience]
  • Nakazawa N, Teruya T, Sajiki K, Kumada K, Villar-Briones A, Arakawa O, Takada J, Saitoh S, Yanagida M (2018) The putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast.  J Cell Sci.  [PubMed]
  • Suma M, Kitagawa T, Nakase Y, Nakazawa N, Yanagida M, Matsumoto T (2018) Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation. G3 (Bethesda).  [PubMed]
  • Xu X, Kanai R, Nakazawa N, Wang L, Toyoshima C, Yanagida M (2018) Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA. Proc Natl Acad Sci U S A [PubMed] 
  • Sajiki K, Tahara Y, Villar-Briones A, Pluskal T, Teruya T, Mori A, Hatanaka M, Ebe M, Nakamura T, Aoki K, Nakaseko Y, Yanagida M (2018) Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast. Open Biology. 8: 170261 [PubMed]
  • Xu X, Wang L, Yanagida M (2018) Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe. G3 (Genes, Genomes, Genetics). 8(3):1031-1038 [PubMed]


  • Inoue H, Sugimoto S, Takeshita Y, Takeuchi M, Hatanaka M, Nagao K, Hayashi T, Kokubu A, Yanagida M, Kanoh J (2017) CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombeGenes Cells. 22(1):59-70 [PubMed]


  • Pluskal T, Yanagida M (2016) Measurement of Metabolome Samples Using Liquid Chromatography-Mass Spectrometry, Data Acquisition, and Processing. Cold Spring Harb Protoc. 2016(12): pdb. prot091561 [PubMed]
  • Pluskal T, Nakamura T, Yanagida M (2016) Preparation of Intracellular Metabolite Extracts from Liquid Schizosaccharomyces pombe Cultures. Cold Spring Harb Protoc. 2016(12) : pdb. prot091553 [PubMed]
  • Pluskal T, Yanagida M (2016) Metabolomic Analysis of Schizosaccharomyces pombe: Sample Preparation, Detection, and Data Interpretation. Cold Spring Harb Protoc.  2016(12) : pdb. top079921 [PubMed]
  • Shah M, Su D, Scheliga JS, Pluskal T, Boronat S, Motamedchaboki K, Campos AR, Qi F, Hidalgo E, Yanagida M, Wolf DA (2016) A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism. Cell Rep. 16(7):1891-902 [PubMed]
  • Nakazawa N, Mehrotra R, Arakawa O, Yanagida M (2016) ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast. Genes Cells. 21(9):978-93 [PubMed] 
  • Kondoh H, Yanagida M (2016) Reply to Mäkinen and Ala-Korpela: Small-scale but accurate metabolomics with high reproducibility for identifying age-related blood metabolites. Proc Natl Acad Sci U S A. 113(25):E3471-2 [PubMed]
  • Pluskal T, Sajiki K, Becker J, Takeda K, Yanagida M (2016) Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions. Genes Cells 21(6):530-42 [PubMed]
  • ​Chaleckis R, Murakami I, Takada J, Kondoh H, Yanagida M (2016) Individual variability in human blood metabolites identifies age-related differences. Proc Natl Acad Sci U S A 113(16):4252-9 [PubMed]
  • Masuda F, Ishii M, Mori A, Uehara L, Yanagida M, Takeda K, Saitoh S (2016) Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 6:19629 [PubMed]


  • Takeda K, Starzinski C, Mori A, Yanagida M (2015) The critical glucose concentration for respiration-independent proliferation of fission yeast, Schizosaccharomyces pombe. Mitochondrion 22:91-95 [PubMed]

  • Nakazawa N, Sajiki K, Xu X, Villar-Briones A, Arakawa O, Yanagida M (2015) RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast. Genes Cells 20(6):481-99 [Pubmed]

  • Xu X, Nakazawa N, Yanagida M. (2015) Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast. PLOS ONE 10(3):e0119347 [Pubmed]


  • Akai Y, Kanai R, Nakazawa N, Ebe M, Toyoshima C, Yanagida M. (2014)  ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding. Open Biol. 4(12):140193 [PubMed]

  • Murakami I, Chaleckis R, Pluskal T, Ito K, Hori K, Ebe M, Yanagida M, Kondoh H. (2014) Metabolism of Skin-Absorbed Resveratrol into Its Glucuronized Form in Mouse Skin. PLOS ONE 9(12):e115359 [PubMed]

  • Saitoh S, Mori A, Uehara L, Masuda F, Soejima S, Yanagida M. (2014) Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling and TOR. Mol Biol Cell 26(2):373-86 [PubMed]

  • Yanagida, M. (2014) The Role of Model Organisms in the History of Mitosis Research. Cold Spring Harbor perspectives in biology 6(9):a015768 [PubMed]

  • Chaleckis, R., Ebe, M., Pluskal, T., Murakami, I., Kondoh, H., and Yanagida, M. (2014) Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites. Mol BioSyst, 10(10):2538-51 [PubMed]

  • Pluskal, T., Ueno, M. and Yanagida, M. (2014) Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S. pombe, and Construction of an Overproduction System. PLOS ONE 9(5):e97774 [PubMed; Correction]

  • Saitoh, S. and Yanagida, M. (2014) Does a shift to limited glucose activate checkpoint control in fission yeast? FEBS Letters 588(15):2373-2378 [PubMed]

  • Hayashi, T., Ebe, M., Nagao, K., Kokubu, A., Sajiki, K. and Yanagida, M. (2014) Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex. Genes to Cells 19(7):541-54 [PubMed]


  • Sajiki K, Pluskal T, Shimanuki M and Yanagida M (2013) Metabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation. Metabolites 3(4):1118-1129 [PubMed]

  • Shimanuki M, Uehara L, Pluskal T, Yoshida T, Kokubu A, Kawasaki Y and Yanagida M (2013) Klf1, a C2H2 Zinc Finger-Transcription Factor, Is Required for Cell Wall Maintenance during Long-Term Quiescence in Differentiated G0 Phase. PLOS ONE 8(10):e78545 [PubMed]

  • Chaleckis R, Pluskal T, Hayashi T, Kondoh H, Yanagida M (2013) Metabolomic analysis of human blood, plasma and red blood cells in comparison with eukaryotic microbe. Rinsho Ketsueki. 54(10):1603-14 [PubMed]

  • Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW (2013) Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2:101-6 [PubMed]

  • TTay Z, Eng RJ, Sajiki K, Lim KK, Tang MY, Yanagida M, Chen ES (2013) Cellular Robustness Conferred by Genetic Crosstalk Underlies Resistance against Chemotherapeutic Drug Doxorubicin in Fission Yeast. PLOS ONE 8(1):e55041 [PubMed]


  • T. Nakamura, T. Pluskal, Y. Nakaseko and M. Yanagida (2012) Impaired CoA synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypo-acetylation and fragile DNA. Open Biology 2(9):120117 [PubMed]

  • T. Pluskal , T. Uehara and M. Yanagida (2012) Highly accurate chemical formula prediction tool utilizing high-resolution mass spectra, MS/MS fragmentation, heuristic rules, and isotope pattern matching. Analytical Chemistry 84(10):4396-403 [PubMed]


  • Akai, Y., Kurokawa, Y., Nakazawa, N., Tonami-Murakami, Y., Suzuki, Y., Yoshimura, S. H., Iwasaki, H., Shiroiwa, Y., Nakamura, T., Shibata, E. and Yanagida, M. (2011) Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing. Open Biology 1(4):110023 [PubMed]

  • Yanagida, M., Ikai, N., Shimanuki, M. and Sajiki, K., (2011) Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases. Philos Trans R Soc Lond B Biol Sci 366(1584):3508-3520   [PubMed]

  • Ikai, N., Nakazawa, N., Hayashi, T. and Yanagida, M. (2011) The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biology 1(3):110007 [PubMed]

  • K. Takeda, Tonthat, N. K., Glover, T., Xu, W., Koonin, E. V. , Yanagida, M. and Schumacher, M. A.. (2011) Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. Proc Natl Acad Sci USA 108(41):16950-16955 [PubMed]

  • M. Shimura, Y. Toyoda, K. Iijima, M. Kinomoto, K. Tokunaga, K. Yoda, M. Yanagida, T. Sata and Y. Ishizaka. (2011) Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation. J Cell Biol [PubMed]

  • K. Takeda, A. Mori and M. Yanagida. (2011) Identification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombePLOS ONE 6(7):e22021 [PubMed]

  • N. Nakazawa, R. Mehrotra, M. Ebe and M. Yanagida. (2011) Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. J Cell Sci:124:1795-1807  [PubMed]

  • Y. Shiroiwa , T. Hayashi , Y. Fujita , A. Villar-Briones , N. Ikai , K. Takeda , M. Ebe and M. Yanagida. (2011) Mis17 Is a Regulatory Module of the Mis6-Mal2-Sim4 Centromere Complex That Is Required for the Recruitment of CenH3/CENP-A in Fission Yeast. PLOS ONE 6:e17761 [PubMed]

  • Kiyomitsu, T. , Murakami, H. and Yanagida, M. (2011) Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1. Molecular and Cellular Biology 5:998-1011 [PubMed]

  • Takahashi K., Imano R., Kibe T., Seimiya H., Muramatsu Y., Kawabata N., Tanaka G., Matsumoto Y., Hiromoto T., Koizumi Y., Nakazawa N., Yanagida M., Yukawa M., Tsuchiya E. and Ueno M. (2011) Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation. Molecular and Cellular Biology (31)3:495-506 [PubMed; Correction]

  • T. Pluskal , T. Hayashi , S. Saitoh , A. Fujisawa and M. Yanagida. (2011) Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast. FEBS J  278:1299-1315  [PubMed]


  • K. Takeda , T. Yoshida , S. Kikuchi , K. Nagao , A. Kokubu , T. Pluskal , A. Villar-Briones , T. Nakamura and M. Yanagida. (2010) Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Proc Natl Acad Sci USA 107:3540-3545  [PubMed]

  • M. Yanagida. (2010) Mostly DNA, a bit of glucose, and the next 50 years. Mol Biol Cell 21:3826  [PubMed]

  • T. Pluskal, S. Castillo, A. Villar-Briones and M. Orešič. (2010) MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics 11:395 [PubMed]

  • K. Takeda and M. Yanagida. (2010) In quiescence of fission yeast, autophagy and the proteasome collaborate for mitochondrial maintenance and longevity. Autophagy 6 [PubMed]

  • Kiyomitsu T, Iwasaki O, Obuse C, Yanagida M. (2010) Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. J Cell Biol. 188:791-807 [PubMed]


  • T. Pluskal, T. Nakamura , A. Villar-Briones and M. Yanagida. (2009) Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbation. Mol BioSyst 6:182-198 [PubMed]

  • M. Yanagida. (2009) Cellular quiescence: are controlling genes conserved? Trends Cell Biol 19:705-715  [PubMed]

  • M. Yanagida. (2009) Clearing the way for mitosis: is cohesin a target? Nat Rev Mol Cell Biol 10:489-496  [PubMed]

  • Hanyu, Y., Imai, K. K., Kawasaki, Y., Nakamura, T., Nakaseko, Y., Nagao, K., Kokubu, A. , Ebe, M., Fujisawa, A., Hayashi, T., Obuse, C. and Yanagida, M. (2009) Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. Genes Cells 14:539-554 [PubMed]

  • K. Sajiki , M. Hatanaka , T. Nakamura , K. Takeda , M. Shimanuki , T. Yoshida , Y. Hanyu , T. Hayashi , Y. Nakaseko and M. Yanagida. (2009) Genetic control of cellular quiescence in S. pombe. J Cell Sci 122:1418-1429 [PubMed]


  • N. Nakazawa , T. Nakamura , A. Kokubu , M. Ebe , K. Nagao and M. Yanagida. (2008) Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis. J Cell Biol 180:1115-1131  [PubMed]

  • Y. Adachi , A. Kokubu , M. Ebe , K. Nagao and M. Yanagida. (2008) Cut1/separase-dependent roles of multiple phosphorylation of fission yeast cohesion subunit Rad21 in post-replicative damage repair and mitosis. Cell Cycle 7:765-776  [PubMed]


  • T. Hayashi , M. Hatanaka , K. Nagao , Y. Nakaseko , J. Kanoh , A. Kokubu , M. Ebe and M. Yanagida. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12:1357-1370  [PubMed]

  • M. Shimanuki , S. Y. Chung , Y. Chikashige , Y. Kawasaki , L. Uehara , C. Tsutsumi , M. Hatanaka , Y. Hiraoka , K. Nagao and M. Yanagida. (2007) Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombeGenes Cells 12:677-692  [PubMed]


  • K. Takeda and M. Yanagida. (2006) [How does fission yeast cut8 regulate the nuclear localization of proteasome?]. Tanpakushitsu Kakusan Koso 51:1241-1244 [PubMed]

  • S. Mochida and M. Yanagida. (2006) Distinct modes of DNA damage response in S. pombe G0 and vegetative cells. Genes Cells  11:13-27 [PubMed]

  • K. Nagao and M. Yanagida. (2006) Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. Genes Cells 11:247-260 [PubMed]


  • K. Takeda and M. Yanagida. (2005) Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Cell 122:393-405 [PubMed]


  • K. Nagao , Y. Adachi and M. Yanagida. (2004) Separase-mediated cleavage of cohesin at interphase is required for DNA repair. Nature 430:1044-1048 [PubMed]


For older publications by Prof. Yanagida's Kyoto University lab, please check this list.