Implication of the chromosome structure and new technologies to elucidate it


Tuesday, February 16, 2016 - 15:00 to 16:00


C015 (Lab1, Level C)


Speaker: Dr. Kiichi Fukui, Professor, Department of Biotechnology, Graduate School of Engineering, Osaka University


Title: Implication of the chromosome structure and new technologies to elucidate it



Although “chromosome” was discovered in the middle of the 19th century, its structure has not been elucidated even now despite of all the efforts of researchers in the fields of biology, molecular biology, biochemistry, biophysics, computer science, etc. Two technologies of focused ion beam and scanning electron microscopy (FIB/SEM) and the super resolution microscopy, three dimensional structured illumination microscope (3D-SIM), were used for the analysis of chromosome higher order structure, especially for its axial structure. The FIB/SEM can produce a serial section and each of them can be observed simultaneously by SEM. As a result, we recently revealed the higher order structure of the chromosome axis (chromosome scaffold) as the twisted double strands like a DNA molecule (Poonperm et al. Sci. Rep. 2015). It is concluded that the nano-technology would be a powerful tool for many aspects of biological researches including chromosome research and would play a key role for elucidation of the long lasting enigma, such as chromosome higher order structure.



Professor Fukui received the Ph.D. degree in Agriculture from Kyoto University in 1978. After his research in Ministry of Agriculture, Forestry, and Fisheries, and Hokuriku Agricultural Experiment Station, Japan, he has been a professor in the laboratory of Dynamic Cell Biology, Graduate School of Engineering at Osaka University since 1998. From 2005 to 2008, he was a special guest professor in the Graduate School of Engineering at the University of Tokyo. He holds the president of The Society Chromosome Research, Japan.



Prof. Mitsuhiro Yanagida, G0 Cell Unit



Norihiko Nakazawa, G0 Cell Unit (



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