Formation and Regulation of Neuronal Connectivity Research Unit (David Van Vactor)

Unit outline

David Van Vactor

Formation and Regulation of Neuronal Connectivity Research Unit

David Van Vactor, Visiting Professor

davie at oist.jp

 

Research

Abstract

The mechanisms that control the formation and maintenance of accurate and functional synaptic connections are vital to the operation of the nervous system.  While much remains to be learned about the molecular machinery underlying the specific directional growth of axons to reach target cells and the formation of synapses in the developing and regenerating nervous system, many of the genes needed for these events have been identified. This foundation of knowledge provides an opportunity to better understand the mechanisms that regulate the deployment of this molecular arsenal during normal development, or in disease states that compromise the function or survival of neural circuits.  Multiple levels of regulatory mechanisms exist, from transcriptional to post-transcriptional and translational control of neural gene expression.  Our interest is to better define such regulatory strategies, using Drosophila melanogaster as a model system to allow genetic dissection of neural development and neurodegeneration in vivo.

 

Education

Prof. Van Vactor, together with Drs. Mahesh Bandy (OIST) and Thomas Clandinin (Stanford University), organizes the Collaborative Experimental Design and Analytics (CEDA) workshop.

This international undergraduate workshop is designed to present students with thematically related research topics in the biological sciences, from organizmal to molecular resolution, which represent phenomena that illustrate fundamental principles. By combining scientific research presentations, foundational lectures, hands-on data collection and quantitative skills workshops, this one-week intensive course will provide opportunities for students to explore cutting edge questions.  Team problem-solving and analysis with statistical and computational tools will be used to deepen collaborative connections while demonstrating fundamentals of experimental design and data interpretation.

 

Contribution to OIST research community

Under construction...