Main Relevant Publications

  1. Ito-Kureha T, Miyao T, Nishijima S, Suzuki T, Kozumi S-I, Villar-Brioness A, Takahashi A, Akinama N, Morita M, Nagura I, Ishikawa H, Ichijo H, *Akinama T, *Yamamoto T. The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nature Commun in press. 2020
  2. Mostafa D, Yanagiya A, Georgiadou E, Wu Y, Stylianides T, Rutter GA, *Suzuki T, *Yamamoto T. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Commun Biol 3:476, 2020 
  3. Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, *Yamamoto T. *Sonenberg N. Hepatic post-transcriptional network comprising of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proc Natl Acad Sci USA 116:7973-7981, 2019
  4. Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, *Yamamoto T. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. Oncogene  38: 2580–2594, 2019
  5. Takahashi A , Adachi S ,Morita M , Tokumasu M , Natsume T , Suzuki T, and *Yamamoto T , Post-Transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity. Cell Rep 13:2756-2767, 2015
  6. Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, and *Yamamoto T. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J 30:4678-4691, 2011