Learn fundamental neural mechanisms of learning and memory, with a focus on memory. Through lectures and journal club presentations, discover connections between synaptic plasticity and memory, and the important role of the hippocampus in different types of memory. Compare and contrast synaptic and systems consolidation mechanisms of memory, and their effects and consequences. Apply this knowledge in preparing a mock grant proposal for a significant question in memory research.
1. Introduction and goals of this course
(short quizzes)
2. Synapse and memory
(short quizzes)
3. Approaches in memory studies
4. Linking synaptic plasticity and memory 1
(short quizzes)
5. Linking synaptic plasticity and memory 2
(short quizzes)
6. Journal Club
Each student chooses a paper for discussion in the class. A list of papers will be given.
7. Systems consolidation
(short quizzes)
8. Anatomy of the Hippocampus and surrounding areas
(short quizzes)
9. Adult neurogenesis (taught by Viviane Saito)
(short quizzes)
10. Hippocampal physiology 1
(short quizzes)
11. Hippocampal physiology 2
(short quizzes)
12. Study Section
Discuss and score research proposals
13. Final exam
short answer quizzes during term (40%), performance during journal club (10%), performance in research proposal/study section (10% /10%), and final exam (30%)
The Neurobiology of Learning and Memory (3rd edition) by Jerry W. Rudy
The Hippocampus Book by Per Andersen, Richard Morris, David Amaral, Tim Bliss & John O’Keefe
From AY2024, this course moves to term 2