Course Coordinator: 
Gordon Arbuthnott
Tomoyuki Takahashi

In this course students learn about the cellular and molecular basis of neuronal functions, and how individual electrical signals are integrated into physiological functions.  The course will stress connections between information, computations, and biological mechanisms in processes underlying motivated behavior, and will be taught by discussion of physiological mechanisms that contribute to such behaviors. Students will learn how to evaluate evidence obtained in laboratory studies conducted with animals. 

This course provides an overview of cellular neurophysiology and how neuronal circuits produce behavior.
Detailed Syllabus: 
Organization of the nervous system 
Ionic basis of excitability and voltage-gated ion channels 
Action potential generation and propagation 
Synaptic transmission, neurotransmitters, neuromodulators
Synaptic ion channels and receptors 
Synaptic plasticity, intracellular signaling, retrograde messengers 
Neural morphology, cytoskeleton, and implications for function 
Neural networks, cerebral cortex, basal ganglia, cerebellum 
Motor system; movement 
Somatosensory systems; Whiskers 
Mechanism of sensory transduction 
Sensory systems Vision and hearing 
Discussion of neurophysiology of brain systems with methods in the awake animal 
Course Type: 
Essay 80%, Lab reports, 20%.
Text Book: 
Neuroscience, 5 edn, by Dale Purves, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, and Leonard E. White (2012) Sinauer
Reference Book: 
The Synaptic Organization of the Brain, 5 edn, Gordon M. Shepherd (2003) OUP
Fine Structure of the Nervous System, 3 edn, Peters Parlay Webster (1991) OUP
The Human Central Nervous System, 4 edn, Nieuwenhuys, Voogd, van Huijzen (2008) Springer
The Central Nervous System, 4 edn, Per Brodal (2010)
Encyclopaedia of Neuroscience (5 volumes) (2009) Springer
Principles of Neural Science, 5 edn, Kandel, Schwartz, Messel, Siegelbaum and Hudspeth (2012) McGraw-Hill
Fundamental Neuroscience 3 edn, Larry Squire, (2008) Elsevier (Academic Press)
Ion Channels of Excitable Membranes, 3 edn, Bertil Hille (2001) Sinauer