Course Coordinator: 
Tadashi Yamamoto
Molecular Oncology and Cell Signalling

This course consists of lectures and exercises. First, students learn, through lectures, recent progress in cancer research and the mechanism of carcinogenesis based on the molecular and cellular functions of oncogenes and anti-oncogenes. Further, students will learn the relevance of signal transduction, cell cycle progression, cell adhesion, and gene regulation to tumor development and are encouraged to simulate effective methods of diagnosis and treatment of cancer. Further, through exercises, students will consider the relevance of genome sciences and systems biology to cancer research.  Students are encouraged to refer to the textbook and to papers from the current literature. The course will also present special novel and important topics from year to year.

This advanced course aims to develop a deep understanding of tumor development, based on recent research developments in the molecular and cellular biology of cancer.
Course Content: 
  1. Historical background of molecular oncology
  2. Viruses, chemical carcinogens, and tumor development
  3. RNA tumor viruses and oncogenes
  4. Discovery of anti-oncogenes
  5. Regulation of signal transduction and cell cycle progression by oncogenes and anti-oncogenes
  6. Roles of oncogenes and anti-oncogenes in normal physiology
  7. Molecular mechanisms of metastasis
  8. Genome, proteome, metabolome, and cancer
  9. Animal models of cancer
  10. Drug development for cancer treatment
  11. Cancer stem cells
  12. microRNA and cancer development
  13. Genome sciences in cancer research
  14. Systems biology in cancer research
Course Type: 
Oral presentation of paper, 50%; Research report, 50%.
Text Book: 
The Biology of Cancer, by Weinberg (2006) Garland Science
Molecular Biology of the Cell, 5 ed, by Alberts, Johnson, Lewis, Raff, Roberts and Walter (2007) Garland Science
Reference Book: 
The Molecules of Life, by Kuriyan, Konforti, and Wemmer (2012) Garland Science
Biochemistry, 7 ed, by Berg, Tymoczko, and Stryer (2010) WH Freeman & Company
Prior Knowledge: 

Requires at least advanced undergraduate level Cell Biology and Genetics or similar background knowledge