Course Coordinator: 
Tomomi Kiyomitsu
Genetics and Modern Genetic Technologies

Genetics is the study of biologically inherited traits. Thus, genetics is related to all living organisms and more or less to all life science fields. In addition, modern genetic technologies not only have a strong impact on basic research, but on applied research as well, such as medicine and agriculture. This course introduces the key concepts of genetics and modern genetic technologies. In parallel to the lectures, students will see or experience CRISPR/Cas9-based genome editing using cultured human cells. Lecturers from outside of OIST may also be invited. The major goal of this course is to learn the key concepts of genetics and modern genetic technologies in order to utilize them and deal with their associated problems.

Students who complete this course will understand the key concepts of genetics and the advantages of modern genetic technologies. In addition, through the exercise of genome editing using cultured human cells, students can realize the power, simplicity of use, and potential risks of genome editing technologies. Target Students 1. Students who majored in biology or life science, and want to review the key concepts of genetics and learn modern genetic technologies. 2. Students who did not major in biology or life science, but are interested in genetics and its associated technologies.
Course Content: 

1. Mendel’s principles of heredity and extensions to Mendel’s laws
2. The chromosome theory of inheritance
3. Linkage, recombination, and the mapping of genes on chromosomes
4. DNA structure, replication, and recombination
5. Anatomy and function of a gene: Dissection through mutation
6. Gene expression and analysis of genetic information
7. Chromosomal rearrangements and changes in chromosome number
8. Bacterial genetics and organellar inheritance
9. Gene regulation in prokaryotes and eukaryotes
10. Manipulating the genomes of eukaryotes
11. The genetic analysis of development and cancer
12. Variation and selection in populations
13. The genetics of complex traits
14. Discussion: Future improvements and ethical issues of genetic technologies
15. Exercise: Genome editing of cultured human cells

Course Type: 
Participation 20%, Examination 40%, and Presentation 40%
Text Book: 
Genetics, From Genes to Genomes, Sixth edition, by Hartwell et al (2018), McGraHill Education
Reference Book: 
Essential Genetics and Genomics, Seventh edition, by Daniel L. Hartl (2020), Jones & Bartlett learning.
Prior Knowledge: 

This course no prerequisite courses.

Suggested to take this course alongside/after B27 Molecular Biology of the Cell