A303
Course Coordinator: 
Ichiro Masai
Developmental Biology
Description: 

This course introduces fundamental principles and key concepts in the developmental processes of animal organisms, by focusing on Drosophila embryonic development and vertebrate neural development as models, and will facilitate graduate students to reach a professional level of understanding of developmental biology. Furthermore, genetic tools for live imaging of fluorescence-labeled cells using Drosophila and zebrafish embryos will be introduced as practical exercises. The course also includes debate on specific topics in developmental biology by students and a writing exercise of mock-grant application. Some lecturers outside OIST will be invited to present particular special topics. 

Detailed Syllabus: 
  1. Basic concepts of developmental biology, and introduction of model systems
  2. Development of the Drosophila embryonic body plan
  3. Organogenesis
  4. Patterning of vertebrate body plan
  5. Morphogenesis
  6. Cell fate decision in the vertebrate nervous system
  7. Current topics of neuronal specification and multipotency of neural stem cells
  8. Axon guidance, target recognition
  9. Synaptogenesis
  10. A model for neurodegeneration in Drosophila
  11. Debate of topics of developmental biology by students
  12. Debate of topics of developmental biology by students
  13. Debate of topics of developmental biology by students
  14. Genetic tools for live imaging of fluorescence-labeled cells using Drosophila
  15. Genetic tools for live imaging of fluorescence-labeled cells using zebrafish
Aim: 
This lecture series will introduce fundamental principles governing development of animal organisms and current research topics
Course Type: 
Elective
Credits: 
2
Assessment: 
Participation 20%; Written Report 40%; Presentation 40%
Text Book: 
Principles of Development 2 edn, Lewis Wolpert (2010) Oxford University Press
Developmental Biology 9 edn, Scott F. Gilbert (2010) Sinauer
Development of the Nervous System 3 edn, Sanes, Reh, Harris (2011) Academic Express