A208
Course Coordinator: 
Fujie Tanaka
Bioorganic Chemistry
Description: 

This course covers essential concepts and recent advances in the design and synthesis of functional molecules used for understanding and controlling biological systems.  Topics of this course include design and synthesis of small organic molecules, organic reactions, methods for controlling reaction pathways, asymmetric synthesis, mechanisms of catalysis and molecular recognition, and creation of designer proteins and peptides.

Aim: 
To discuss design and synthesis of functional molecules used for understanding and controlling biological systems.
Detailed Syllabus: 
  1. Methods of chemical transformations to access designer molecules
  2. Strategies for the development of new reaction methods including stereoselective reaction methods
  3. Asymmetric reactions and asymmetric catalysis
  4. Catalytic enantioselective reactions: Carbon-carbon bond forming reactions
  5. Catalytic enantioselective reactions: hydrolysis, reduction, dynamic kinetic resolutions, etc.
  6. Design and synthesis of functional molecules
  7. Chemical mechanisms of bioactive molecules including chemistry of enzyme inhibitors
  8. Molecular recognition and non-covalent bond interactions
  9. Enzyme catalysis and catalytic mechanisms
  10. Enzyme catalysis and small organic molecule catalysis
  11. Enzyme kinetics and kinetics of non-enzymatic reactions
  12. Strategies for the development of new designer catalysts
  13. Methods in identification and characterization of organic molecules
  14. Strategies for the development of designer functional proteins and peptides
  15. Chemical reactions for protein labeling; chemical reactions in the presence of biomolecules
Course Type: 
Elective
Credits: 
2
Assessment: 
Exercises 50%, reports 50%
Text Book: 
Advanced Organic Chemistry, Part A: Structures and Mechanisms, Part B: Reactions and Synthesis, 5th edn, Carey and Sundberg (2007)
Reference Book: 
Modern Physical Organic Chemistry, Anslyn and Dougherty (2005)
The Organic Chemistry of Drug Design and Drug Action, 2nd edn, Silverman (2004)
Organic Chemistry, 7th Edition, McMurry (2008)