A208
Course Coordinator: 
Fujie Tanaka
Bioorganic Chemistry
Description: 

This course covers essential concepts and recent advances in the design and synthesis of functional molecules used for understanding and controlling biological systems.  Topics of this course include design and synthesis of small organic molecules, organic reactions, methods for controlling reaction pathways, asymmetric synthesis, mechanisms of catalysis and molecular recognition, and protein modification reactions.
Target students
Students who are interested in synthetic organic chemistry related to life sciences
Student Learning Outcomes
Students successfully completing this course will gain an understanding on chemistry of functions of organic molecules and chemical transformations of organic molecules.
Learning Assessments
Assignment Exercises: Each person selects two papers (at least one is from the list provided at the first class) and explains/interprets the research and the topic described in the papers in front of the course audience ((one paper at one time x 2 times)/person).  A 4-10 pages-summary may be prepared to distribute to the audience. Although presenting paper is one per each time per person, related papers (i.e., references of the paper) may also be checked and included in the summary.
Assignment Report: Select one paper from the journals list provided at the first class and write a report on it (a 1-4 pages-report).  Instruction how to write the report is provided at the class.
Quizzes are provided frequently, but these are not used for grading.
Grading expectations
To obtain an A grade, attending all or most classes and completing the exercises and the report described above are required. If the exercises described above are not done and/or if the report is not submitted, the course credit may not be awarded (i.e., resulting in F).

Aim: 
To discuss design and synthesis of functional molecules used for understanding and controlling biological systems.
Course Content: 
  1. Methods of chemical transformations to access designer molecules
  2. Strategies for the development of new reaction methods including stereoselective reaction methods
  3. Asymmetric reactions and asymmetric catalysis
  4. Catalytic enantioselective reactions: Carbon-carbon bond forming reactions
  5. Catalytic enantioselective reactions: hydrolysis, reduction, dynamic kinetic resolutions, etc.
  6. Organocatalysis
  7. Design and synthesis of functional molecules
  8. Chemical mechanisms of bioactive molecules including chemistry of enzyme inhibitors
  9. Molecular recognition and non-covalent bond interactions
  10. Catalysis and catalytic mechanisms by organic molecules
  11. Enzyme catalysis and small organic molecule catalysis
  12. Enzyme kinetics and kinetics of non-enzymatic reactions
  13. Strategies for the development of new designer catalysts
  14. Methods in identification and characterization of organic molecules
  15. Chemical reactions for protein labeling; chemical reactions in the presence of biomolecules
Course Type: 
Elective
Credits: 
2
Assessment: 
Exercises 50%, reports 50%
Text Book: 
Strategic Applications of Named Reactions in Organic Synthesis, Kurti and Czako (2005)
Advanced Organic Chemistry, Part B: Reactions and Synthesis, Carey and Sundberg (2007)
Reference Book: 
Advanced Organic Chemistry, Part A Structures and Mechanisms, Carey and Sundberg (2007)
Organic Chemistry, McMurry
Prior Knowledge: 

Students are expected to have studied organic chemistry and/or biochemistry or related chemistry at the undergraduate level.