Course Coordinator: 
Hidetoshi Saze

Epigenetic regulation of gene activity is essential for development and response to environmental changes in living organisms. Discover fundamental principles and key concepts of epigenetics, including the specific molecular mechanisms and structural changes. Examine these changes in the context of modifying factors such as transposable elements, RNA interference, and dosage compensation. Discuss recent advances in epigenetic reprogramming, stem cell applications, and the influence of epigenetic changes on disease. Critically review and discuss original research publications about epigenetic phenomena.

This course provides an overview of the principles of epigenetics to students with background of molecular biology and genetics.
Course Content: 
  1. Introduction to Epigenetics
  2. Histone variants and modifications
  3. DNA methylation
  4. RNA interference and small RNA
  5. Regulation of chromosome and chromatin structure
  6. Transposable elements and genome evolution I
  7. Transposable elements and genome evolution II
  8. Epigenetic regulation of development I
  9. Epigenetic regulation of development II
  10. Genome imprinting
  11. Dosage compensation I
  12. Dosage compensation II
  13. Epigenetic reprogramming and stem cells
  14. Epigenetics and disease 
  15. Epigenomics
Course Type: 
Participation 50%; Presentation, 50%
Text Book: 
  • Epigenetics, by Allis, Jenuwein, Reinberg, Caparros (2006) Cold Spring Harbor Laboratory Press
Reference Book: 
  • Introduction to Genetic Analysis, 10 edn, by Griffiths et al. (2010) W.H. Freeman and Company
  • Molecular Biology of the Cell, 5 edn, by Alberts et al. (2007) Garland Science
Prior Knowledge: 
Requires at least advanced undergraduate level Cell Biology and Genetics or similar background knowledge