Peer reviewed research articles:

Kawata S, Mukai Y, Nishimura Y, Takahashi T, Saitoh N. (2022). Green fluorescent cAMP indicator of high speed and specificity suitable for neuronal live-cell imaging. Proc. Natl. Sci. USA. 119(28):e2122618119.; doi: 10.1073/pnas.2122618119. Epub 2022 Jul 6.PMID: 35867738

Hori T, Eguchi K, Wang HY, Miyasaka T, Guillaud L, Taoufiq Z, Mahapatra S, Yamada H, Takei K, Takahashi T. (2022). Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model. eLife. 11:e73542.; doi: 10.7554/eLife.73542.PMID: 35471147 

Hori T, and Takamori S. Physiological Perspectives on Molecular Mechanisms and Regulation of Vesicular Glutamate Transport: Lessons From Calyx of Held Synapses. 
Front. Cell. Neurosci., 13 January 2022 |

Nojima K, Miyazaki H, Hori T, Vargova L, Oohashi T.
Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held. Front Cell Dev Biol. 2021; 9: 730550. Published online 2021 Sep 17. doi: 10.3389/fcell.2021.730550

Taoufiq Z., Ninov M., Villar-Briones A., Wang H.Y., Sasaki T., Roy M.C., Beauchain F., Mori Y., Yoshida T., Takamori S., Jahn R., Takahashi T. (2020). Hidden proteome of synaptic vesicles in the mammalian brain. Proc. Natl. Sci. USA. 118(52):33586-33596; doi: 10.1073/pnas.2011870117

Wang H.Y., Eguchi K., Yamashita Y., Takahashi T. (2020). Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. J Neurosci. 40(21):4103-4115; doi:10.1523

Ananda Babu L.P, Wang H.Y., Eguchi K., Guillaud L., Takahashi T. (2020) Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. J. Neurosci. 40, 131-142.

Yamashita M., Kawaguchi S., Hori T., Takahashi T. (2018) Vesicular GABA uptake can be rate limiting for recovery of IPSCs from synaptic depression. Cell Rep. 22, 3134-3141.

Eguchi K., Taoufiq Z., Thorn-Seshold O., Trauner D., Hasegawa M., Takahashi T. (2017) Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fidelity via tubulin polymerization at the calyx of Held. J. Neurosci. 37, 6043-6052.

Guillaud L., Dimitrov D., Takahashi T. (2017) Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses.  eLife 6: e24845.

Takami C., Eguchi K., Hori T., Takahashi T. (2017) Impact of vesicular glutamate leakage on synaptic transmission at the calyx of Held. J. Physiol. 595: 1263-1271.

Dimitrov D., Takagi H., Guillaud L., Saitoh N., Eguchi K., Takahashi T. (2016) Reconstitution of giant mammalian synapses in culture for functional and imaging studies. J. Neurosci. 36, 3600-3610.

Nakamura Y., Harada H., Kamasawa N., Matsui K., Rothman J.S., Shigemoto R., Silver R.A., DiGregorio D.A., Takahashi T. (2015) Nanoscale distribution of presynaptic Ca2+channels and its impact on vesicular release during development. Neuron. 85, 145-158.

Guillaud, L., Gray, K. T., Moroz, N., Pantazis, C., Pate, E., Kostyukova, A. S.
"Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes." Biochemistry 53(16): 2689-2700.

Miki T., Hirai H., Takahashi T. (2013) Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release. J. Neurosci. 27, 18755-18763.

Taoufiq Z.*, Eguchi K.*, Takahashi T. (2013) Rho-kinase accelerates synaptic vesicle endocytosis by linking cyclic GMP-dependent protein kinase activity to phosphatidylinositol-4,5-bisphosphate synthesis. J. Neurosci. 33, 12099-12104. *Co-first authors

Zhou, R., Niwa, S., Guillaud, L., Tong, Y. & Hirokawa, N.  A Molecular Motor, KIF13A, Controls Anxiety by Transporting the Serotonin Type 1A Receptor. Cell Rep 3, 509-519, doi:10.1016/j.celrep.2013.01.014 (2013).

Moroz, N., Guillaud, L., Desai, B. a. K., A. & contribution), e.  Mutations changing tropomodulin affinity for tropomyosin alters neurite formation and extension. PeerJ, doi:10.7717/peerj.7 (2013).

Hori T. and Takahashi T. (2012) Kinetics of synaptic vesicle refilling with neurotransmitter glutamate. Neuron 76, 511-517.

Eguchi K., Nakanishi S., Takagi H., Taoufiq Z., Takahashi  T. (2012) Maturation of a PKG-dependent retrograde mechanism for exo-endocytic coupling of  synaptic vesicles. Neuron 74, 517-529.

Arama, J., Boulay, A. C., Bosc, C., Delphin, C., Loew, D., Rostaing, P., Amigou, E., Ezan, P., Wingertsmann, L., Guillaud, L., Andrieux, A., Giaume, C. & Cohen-Salmon, M.  Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions. PLoS One 7, e35488, doi:10.1371/journal.pone.0035488 (2012).

Takagi, H., Setou, M., Ito, S. & Yao, I.  SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses. Neural Plast 2012, 7 pages, doi:10.1155/2012/352829 (2012).

Yamashita T., Eguchi K., Saitoh N., von Gersdorff H., Takahashi T. (2010). Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+. Nat. Neurosci. 13, 838-844.

Watanabe H., Yamashita T., Saitoh N., Kiyonaka S., Iwamatsu A., Campbell K.P., Mori Y., Takahashi T. (2010). Involvement of Ca2+ channel synprint site in synaptic vesicle endocytosis. J. Neurosci. 30, 655-660.


Review articles:

Takahashi T. (2020). Presynaptic black box opened by pioneers at Biophysics Department in University College London. Neuroscience 439, 10-21.

Takahashi T. (2015). Strength and precision of neurotransmission at mammalian presynaptic terminals. Proc Japan Acad, Ser B 91, 305-320.

Takahashi T. (2005). Postsynaptic receptor mechanisms underlying developmental speeding of synaptic transmission. Neuroscience Res. 53, 229-240.

Takahashi T. (2005). Dynamic aspects of presynaptic calcium currents mediating synaptic transmission. Cell Calcium 37, 507-511.

Takahashi T., Kajikawa Y., Kimura M., Saito N. & Tsujimoto T. (2004). Presynaptic mechanism underlying regulation of transmitter replase by G protein coupled receptors. Korean J. Physiol. Pharmacol. 8, 69-76.

Otsuka M.and  Takahashi T. (1977). Putative peptide neurotransmitters. Ann. Rev. Pharmacol. Toxicol.17, 425-439.



Dimitrov D., Guillaud L., Eguchi K., Takahashi T. (2018) Culture of Mouse Giant Central Nervous System Synapses and Application for Imaging and Electrophysiological Analyses. In: Skaper S. (eds) Neurotrophic Factors. Methods in Molecular Biology, vol 1727, 201-215.