Principal Investigator

       Ye Zhang (Assistant Professor)

B.S. Nankai University
Ph.D. Hong Kong University of Science and Technology (

Professional Experience

  • Postdoc Fellow, University of Turin, Italy
  • Postdoc Fellow, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland
  • Visiting Scholar, Norwegian University of Science and Technology (NTNU), Norway
  • Postdoc Associate, Brandeis University, USA

Invited talks

  • The 11th Chinese National Conference on Chemical Biology, Chinese Chemical Society (November, 2019)                                                               
  • 70th Anniversary of the Division Meeting of Division of Colloid and Surface Chemistry, The Chemistry Society of Japan (November, 2019)                                                                                         
  • The SPIRITS International Symposium--Kyoto University, Japan (March, 2019) 'Regulate Hippo signaling via lipid-raft-targeted molecular assembly for ovarian cancer treatment'                               
  • School of Chemistry, Sun Yat-sen University, China (November, 2018) 'Control of the tumorigenic signaling pathway via membrane-protein-targeted peptide assembly'                                                  
  • Institute of Biochemistry and Cell Biology (IBCB), SIBS, CAS, China (September, 2018) 'Control of the tumorigenetic signaling pathway via assembly of integrin-targeted synthetic peptides'                
  • IMCE International Symposium--Kyushu University, Japan (March, 2018) 'Regulate Cancer Cell Mechanics by Synthetic Molecular Self-assembly'                                          
  • 24rd EAJS--Kyoto University, Japan (October, 2017) 'Tie up cytoskeleton to inhibit ovarian cancer metastasis'                                                                        

Select Publications


  • Zhang, Y.; Xu, B. “Polymeric Materials Having Active Cross-linkers, Methods for Making Them, and Use Thereof” US Patent 43022.0100.

Book Chapter

  • Zhang, Y.; Xu, B.* “Superactivity of Enzymes in Supramolecular Hydrogels” in Proteins in Solution and at Interfaces: Methods and Applications in Biotechnology and Materials Science. Wiley, 2013, ISBN: 9780470952511

Selected Journal Article

  • Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Yazhou chen, Toshio Sasaki, Hui Chao,* and Ye Zhang.* "Construct Sturdy Packing of Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking" Angew. Chem. Int. Ed. 2021, accepted
  • Guanying Li, Xunwu Hu, Pingping Nie, Dingze Mang, Shi Jiao, Shijin Zhang, Sona Roy, Sachie Yukawa, Shunsuke Asahina, Hiroaki Sugasawa, William Cortes, Zhaocai Zhou,* and Ye Zhang.* "Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Treat Ovarian Cancer" Nano Letters, 2020,                                                                           
  • Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, and Ye Zhang.* "Regulate  Higher-order Organization through the Synergy of Two Self-sorted Assemblies" Angew. Chem. Int. Ed. 2018, 57, 3636-3640
  • Guanying Li, Toshio Sasaki, Shunsuke Asahina, Michael C. Roy, Toshiaki Mochizuki, Koji Koizumi  and Ye Zhang.* “Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration” Chem2017, 2, 283-298.

  • Qingcong Wei, Mengchi Xu, Chuanan Liao, Qing Wu, Mingyu Liu, Ye Zhang,* Chengtie Wu,* Liming Cheng and Qigang Wang.*  "Printable hybrid hydrogel by dual enzymatic polymerization with superactivity" Chemical Science, 2016, 7, 2748.

  • Zhang, Y.; Zhou, N.; Shi, J. F.; Pochapsky, S. S.; Pochapsky, T. C.; Zhang, B.; Zhang, X. X.; Xu, B.* “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nature Commun. 2015, 6, 6165.

  • Zhang, Y.; Zhou, N.; Kim, D.; Fraden, S.*; Epstein, I. R.*; Xu, B.* “ Giant Volume Change of Active Gels under Continuous Flow” J. Am. Chem. Soc., 2014, 136, 7341-7347.
  • Zhang, Y.; Zhou, N.; Akella, S.; Kuang, Y.; Kim, D.; Schwartz, A.; Bezpalko, M.; Foxman, B. M.; Fraden, S.; Epstein, I. R.*; Xu, B.* “ Active Hyper Crosslinkers Confer Active Gels” Angew. Chem. Int. Ed. 2013, 52, 6944-6948.
  • Zhang, Y.; Zhang, B.; Kuang, Y.; Gao, Y.; Shi, J.; Zhang, X. X.; Xu, B.* “A Redox Responsive, Fluorescent Supramolecular Metallohydrogel Consists of Nanofibers with Single-Molecule Width” J. Am. Chem. Soc., 2013, 135, 5008-5011.
  • Zhang, Y.; Li, N.; Delgado, J.; Gao, Y.; Kuang, Y.; Fraden, S.; Epstein, I. R.*; Xu, B.* “Post-Self-Assembly Crosslinking of Molecular Nanofibers for Oscillatory Hydrogels” Langmuir, 2012, 28, 3063-3066.
  • Zhang, Y.; Kuang, Y.; Gao, Y.; Xu, B.* “Versatile Small Molecule Motifs for Self-assembly in Water and Formation of Biofunctional Supramolecular Hydrogels” Langmuir, 2011, 27, 529-537.