As a radiation biologist, I am interested in the biological effects of ionizing radiation, both in terms of radiation-induced risks and in the context of cancer radiation therapy. I have developed a strong interest in Cancer Stem Cells (CSCs), which are proposed to be responsible for tumor expansion, relapse and metastasis. In 2016, I joined the AMI Unit in OIST to better understand CSCs and develop anti-CSC strategies, in combination with innovative radiation therapy modalities.
- Vares, G., Sai, S., Wang, B., Fujimori, A., Nenoi, M., & Nakajima, T. (2015). Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells. Cancer letters, 362(2), 167-173.
- Vares, G., Cui, X., Wang, B., Nakajima, T., & Nenoi, M. (2013). Generation of breast cancer stem cells by steroid hormones in irradiated human mammary cell lines. PloS one, 8(10), e77124.
- Varès, G., Wang, B., Tanaka, K., Kakimoto, A., Eguchi-Kasai, K., & Nenoi, M. (2011). Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 712(1), 49-54.
- Vares G., K, Ory, B. Lectard, C. Levalois, S. Altmeyer-Morel, S. Chevillard and J. Lebeau. 2004. Progesterone prevents radiation-induced apoptosis in breast cancer cells. Oncogene 23(26):4603-13.